Influence of Different Modes of Oxygenation of the Small Intestinal Mucosa in vitro on Glucose and Maltose Accumulation

Glucose accumulation by the everted sacs of the rat small intestine has been investigated during mucosal, serosal and bilateral oxygenations. The conditions are described under which active accumulation of glucose is provided by serosal but not only mucosal oxygenation. It has been found that the active accumulation of glucose during the bilateral oxygenation is approximately equal to the sum of those during the serosal and mucosal oxygenations. The relative roles of the serosal and mucosal modes of oxygenation vary in the fed and fasting animals, as well as in the different segments of the small intestine. The results obtained may be explained by the hypothesis on the existence of two types of cell respiration — apical and basolateral.